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Dose tolerance is another factor
An alternative approach in the design of effective synthetic co-agonists has been to modify GLP-1 analogues to confer increased GCG activity
PMID: 8227353 Secondary Connectivity Map / Broad Transcriptomics Gene Expression Modulation (4,048 Genes) Microarray and CMap analysis reveal that GHK-Cu modulates the expression of 4,048 genes in human fibroblast culturesapproximately 6% of the human genomeaffecting pathways for tissue remodeling, antioxidant defense, anti-inflammatory signaling, and stem cell markers
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Biochem Biophys Res Commun 290:4752 Lee JW, Miyawaki H, Bobst EV et al (1999) Improved functional recovery of ischemic rat hearts due to singlet oxygen scavengers histidine and carnosine
