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GLP-1 agonists, such as ROSE-010, relieve pain in IBS patients by altering gut motility (43), lowering inflammation (44), modulating neurotransmitters (45), reducing visceral hypersensitivity (46), and interacting with the gut microbiota (47)
Weight loss was about 6% lower in men than in women in both groups, the authors noted
Some earlier studies reported discontinuation rates of up to 27% with liraglutide, compared with 510% with tirzepatide
Officials might need to plan for a bump in costs and take steps to avoid a budgetary shortfall, such as negotiating lower prices for the drugs
What remains unknown is the long-term safety profile, because no long-term studies were ever completed
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