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Interventional procedures can help trigeminal neuralgia when medication is not enough, when the diagnosis needs confirmation, or when a peripheral trigeminal branch appears to be the main pain generator

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MSC could improve fibrosis by downregulating or blocking the expression of secreted Frizzled-related protein 2 (sFRP2) and its downstream target Axin2, as well as increasing angiogenesis, suggesting that sFRP2 may be a potential target of action in MSC for the treatment of fibrotic disease models [136]

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