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Just as important, theyll check for any contraindicationssuch as pregnancy plans, certain endocrine conditions, or a history of gallbladder or pancreatic diseasethat could affect whether GLP-1 medications are appropriate or safe

0.33g of the crude Boc-His (Trt) -Aib-OSu and 1g of Compound 2 obtained in example 3 were dissolved in 20mL of N, N-dimethylacetamide, and 2mL of N, N-diisopropylethylamine was added and reacted at room temperature for 8 hours to obtain Compound 4 having a purity of 77.23%, and a specific liquid phase diagram is shown in FIG