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Under hypoxic conditions, L-2-hydroxyglutarate (L-2-HG) was proven to be generated by lactate dehydrogenase A (LDHA) and malate dehydrogenase (MDH) 88,89
Recent advances in the knowledge of cancer biology led to the development of a new diagnostic and therapeutic arsenal that is not limited to selective target drugs but also includes already existing drugs that are multi-targeted or used in polypharmacology (Gonzalez-Fierro and Dueas-Gonzlez, 2021)
Many cases are harmless and directly related to the medicine and black poop triggers or specific foods you have consumed
Understanding the tumor immune microenvironment (TIME) for effective therapy
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