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Plasma glutathione is typically lower (15 mol/L) and reflects acute oxidative demand
Circadian disruption and sleep deprivation compromise glucose metabolism, increase nocturnal oxidative stress, and suppress glutathione recycling capacity during periods when mitochondrial repair should be prioritized
The average values rise by 1.5 to 2-times the normal levels, with most of this elevation observed in the morning
for example, elevated Asp may be accompanied by enhanced IL-1 production and promote an M1-like polarization tendency, and the underlying mechanism may be related to enhanced HIF-1 stability and activation of inflammasome-related pathways (70)
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