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This has led to increased interest in the development of medications that mimic GLP-1s effects, offering new avenues for treating obesity and type 2 diabetes

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If you regain more than 5% of your target weight, its a sign that the taper may need adjustment, or in some cases, a temporary return to the medication

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Among genetic alterations, single-nucleotide polymorphisms (SNPs) are most implicated, with five reproducible risk loci most consistently associated with MASLD/MASH: patatin-like phospholipase domain-containing protein 3 (PNPLA3), hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13), transmembrane 6 superfamily member 2 (TM6SF2), membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), and glucokinase regulatory protein (GCKR) [47]

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Endocrinology and Metabolism, 34 (3), 247

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Canadian Journal of Surgery

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