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In the first step, NADPH reduces flavin partition, then flavin is oxidized and a redox-active disulfide bridge is reduced, thereby producing a thiolate anion and a cysteine
10.1056/NEJMoa050493 11 ButtgereitF.BurmesterG
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Increases in ferritin and body iron stores have been detected frequently in NAFLD patients [22, 23]
Surprisingly, statins are thought to activate ferroptotic cell death through inhibition of selenoprotein synthesis via the mevalonate pathway, as well as inhibition of GPx4 activity (Costa et al
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