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Because both participants and investigators knew which treatment was being administered, the trial introduced a degree of bias that does not affect the blinded pivotal trials

However, NHS access criteria are more restrictive, typically requiring referral to specialist weight management services and higher BMI thresholds (generally 35 kg/m with comorbidities, with lower thresholds for some ethnic groups)

If maximum tolerable dose is already used, then consider switching to an alternative obesity medication, adding intensive lifestyle therapy, combining obesity medications, or referring to metabolic-bariatric surgery

As of July 1, 2026, the MDLs case count has risen to 3,848

Peaks price is identical at every dose, so savings compound as you titrate up