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Besides the well-known targets such as the inhibition of the mTOR signaling pathway, several additional metformin and phenformin targets (e.g., mGPDH, ATF3, STAT3, GSK3, cyclins) have been identified in other cancers (Thakur et al., 2019)
PMID 18794526
They can be removed with laser or surgery
Available from: Gevaert AB, Shakeri H, Leloup AJ, Van Hove CE, De Meyer GR, Vrints CJ, et al
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