## Best Day of Week to Take a GLP-1: Work and Social Considerations Beyond pure side-effect timing, the best day of week to take a GLP-1 depends on several schedule factors: **Social commitments:** GLP-1 nausea can make eating difficult and significantly lowers alcohol tolerance

It depends on: Plan metal tier (Bronze, Silver, Gold) Formulary tier (Tier 3 vs Tier 4) Whether you have met your annual deductible Whether your plan uses coinsurance or fixed copays Example 1: Bronze plan, Tier 4, deductible not met Plan: Ambetter Balanced Care 2 (Bronze, Georgia) Annual deductible: $6,000 Ozempic formulary tier: Tier 4 Cost before deductible: Full price ($968.52 per 30-day supply) Cost after deductible: 40% coinsurance = $387.41/month Annual cost if using Ozempic all year: $6,000 (deductible) + $2,324.46 (6 months coinsurance) = $8,324.46 Example 2: Silver plan, Tier 3, deductible met Plan: Ambetter Essential Care 4 (Silver, Illinois) Annual deductible: $3,000 (already met) Ozempic formulary tier: Tier 3 Cost after deductible: $200 copay per 30-day supply Annual cost for remaining 8 months: $1,600 Example 3: Gold plan, Tier 3, no deductible for drugs Plan: Ambetter Secure Care 10 (Gold, North Carolina) Drug deductible: $0 Ozempic formulary tier: Tier 3 Cost from day one: $150 copay per 30-day supply Annual cost: $1,800 The table below shows estimated annual out-of-pocket costs for Ozempic across common Ambetter plan types, assuming 12 months of treatment: For comparison, 12 months of compounded semaglutide through FormBlends costs $3,564 to $4,164 depending on dose, with no deductible and no prior authorization required

BPC-157, TB-500 and injectable GHK-Cu are research compounds not approved for human use, and this content is not a recommendation to use them
Groneberg DA, Folkerts G, Peiser C, Chung KF, Fischer A
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