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This minimum interval prevents excessive drug accumulation and reduces the risk of adverse effects, particularly gastrointestinal symptoms
In the SURMOUNT-5 trial, tirzepatide produced an average weight reduction of 20.2% (about 50 lbs) over 72 weeks, compared with 13.7% (about 33 lbs) for injectable semaglutide
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Its sequence incorporates several amino-acid substitutions and an intramolecular disulfide bridge between two cysteine residues, together with a lipidation (fatty-acid acylation) modification that promotes reversible binding to serum albumin
Preprint at medRxiv (2020)
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