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Wegovy and Trulicity are GLP-1 receptor agonists, medications that reduce appetite to support weight loss and improve blood glucose control through various mechanisms
Mitigation: Resistance training and high protein intake (1.6g to 2.2g per kg of body weight) are non-negotiable requirements to preserve muscle during treatment
In principle their mechanisms are complementary a point that becomes relevant when we discuss combination protocols
The addition of GIP seems to further improves insulin sensitivity and may directly influence adipose (fat) tissue metabolism
Reddy CC, Scholz RW, Massaro EJ
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