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Administered weekly at 2.4 mg subcutaneously, semaglutide has secured regulatory clearance in the United States, Europe, the United Kingdom, and Canada for weight management in adults grappling with overweight (BMI 27 kg m2 alongside at least one obesity-related comorbidity) or obesity (BMI 30 kg m2), backed by findings from the Semaglutide Treatment Effect in People with Obesity (STEP) clinical trial program

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Stereotaxic surgical approach to microinject the caudal brainstem and upper cervical spinal cord via the cisterna magna in mice

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