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The gap between trial and real-world tirzepatide vs semaglutide outcomes comes mostly from discontinuation and under-titration: only 25.9% of tirzepatide users reach 15 mg in practice, versus 83.5% of semaglutide users reaching 2.4 mg in the trial

Article Summary GLP-1 medications like semaglutide have transformed obesity and diabetes treatment, helping millions lose weight and improve metabolic health

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While beneficial for most patients, Semaglutide might also have side effects such as nausea, heartburn, headache, and more

Identity and relationship shifts : Significant weight loss changes how people see themselves and how others respond to them