This does not produce meaningful pharmacological synergy and would simply double the cortisol and selectivity tradeoffs of GHRP-2 without a clear mechanistic benefit over ipamorelin alone
They consider other therapies such as bioidentical hormone therapy or desiccated T3 thyroid treatment to ensure a holistic approach
Study selection The criteria for including studies in this meta-analysis were as follows: (1) (i) randomized controlled trials (RCTs) comparing different AOMs with placebo, including glucagon-like peptide 1 receptor agonist (GLP-1 RA), dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 RAs, GLP-1 and glucagon receptor (GCGR) dual-agonist, orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and bimagrumab
American Diabetes Association Professional Practice Committee, ElSayed NA, Aleppo G, et al
For patients with type 2 diabetes also on Zepbound, the same short course usually still doesn't require stopping Zepbound, but adding finger-stick glucose monitoring 2 to 4 times daily during and for 3 days after the steroid course is reasonable