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It works by mimicking two gut hormones: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) that help regulate blood glucose, reduce appetite and promote a longer-lasting feeling of fullness
A 2024 systematic review of semaglutide trials found lean mass loss ranging from zero to about 40 percent of total weight lost depending on the study, while the proportion of lean mass relative to total body weight actually increased
Eligibility depends on eGFR and cardiovascular risk status
doi:10.1177/17455057251384412
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