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After matching 168,428 patients in each group, GLP-1 receptor agonist users had a VTE rate of 11.0 per 1,000 patient-years compared to 12.9 per 1,000 patient-years in those taking DPP-4 inhibitors (a different class of diabetes medication)
One was studied in controlled trials with defined adverse-event reporting
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Regarding the central mechanism of feeding regulation, proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are key anorexigenic neurons
2 to 5 capsules up to 4 times per day
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