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Side Effects Possible side effects of phentermine include: Increased heart rate High blood pressure Effect on alertness Restlessness Various heart disease Dizziness Insomnia Diarrhea Constipation Dry mouth Ozempic vs Phentermine Despite Ozempic and phentermine both being used to achieve weight loss goals, they have quite a few key differences, as discussed below: Which of the Two Weight Loss Drugs Is Most Effective