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That pharmacokinetic difference is the foundation for everything the literature documents about its downstream effects, from receptor activation patterns to the study timelines researchers use to observe change
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This effect arises because of the nonlinear inhibition of GCL and GS by GSH [Figure 2B]
78 These changes stabilize its structure, prevent protein degradation of the molecule in the circulation, and increase the circulation time enough to ensure once-daily injection (compared with exenatide, which is injected two or three times daily)
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