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However, abnormal desensitization of insulin signaling has been observed in the brain tissue of patients with AD even in the absence of DM (Frlich et al., 1998)

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Common adverse events were predominantly gastrointestinal, particularly nausea, vomiting, diarrhoea, and constipation, and represented the most consistently reported adverse effects and the principal cause of treatment discontinuation

Without lab testing, it is difficult to know whether symptoms are related to low hormones, poor sleep, insulin resistance, thyroid imbalance, inflammation, nutrient deficiencies, or another underlying issue

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