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Inoltre, i GLP-1RA inibiscono lespansione mesangiale, riducono lespressione a livello endoteliale di molecole pro-fibrotiche e aumentano la disponibilit di ossido nitrico intraglomerulare, rallentando quindi la progressione della DKD [3334]

Obesity is an independent risk factor for cardiovascular disease and a modulator of other risk factors, hence, weight-reducing therapies are important in managing of these risk

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Although robust evidence is lacking for the primary prevention of cardiovascular disease using a combination of SGLT2is and GLP1-RAs, meta-analyses suggest potential benefits