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Deficiency after LAGB is primarily driven by reduced intake of B12-rich foods and use of acid-suppressing medicines such as PPIs or H2RAs

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Patients arriving with acute soft-tissue injuries get evaluated differently from patients with chronic joint pain or patients planning post-surgical recovery

In 2017, Neelakantan and colleagues first systematically characterized 5amino1mq during screening for selective NNMT inhibitors, with findings published in Biochemical Pharmacology - marking the official discovery and public reporting of the compound.Through structural modification of quinolinebased precursors, the team identified 5amino1mq as a small, membranepermeable molecule with the chemical formula CHN.With an extremely low IC value, it became one of the most promising selective NNMT inhibitors available at the time, with high specificity and no significant inhibition of other metabolically relevant enzymes