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Principle of Action: The drug works by inhibiting the synthesis of AGT mRNA in the liver, reducing the production of AGT protein at its source to achieve long-lasting blood pressure reduction
( ( Summary Injectable GLP-1 medications have the strongest evidence for clinically significant weight loss and predictable dosing
How does GLP-1 medication affect the gut
On July 10, 2024, Kuei-Pin Huang and colleagues published a paper in Nature titled Dissociable Hindbrain GLP1R Circuits for Satiety and Aversion. The study suggests that future weight loss medications could selectively target GLP1R neurons in the nucleus of the solitary tract (NTS) to avoid inducing aversion, thereby improving treatment adherence and effectiveness [1]
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Sue DeCotiis, who specializes in regenerative medicine and prescribes GLP-1 medications in her practice, said retatrutide works by adding a third hormonal pathway glucagon on top of the dual GLP-1 and GIP mechanism already found in tirzepatide, sold as Mounjaro and Zepbound
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