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These isoforms have distinct cellular roles but possess high sequence identity (66%) and comparable enzyme properties

J.et al (2020)

Mood Swings: Understanding Depression and Anxiety People may experience new onset or a worsening of depression and anxiety symptoms, which can manifest as sudden irritability for no apparent reason

This looks like an observational study though, so we can't rule out if these confounding factors may have influenced the final results

These changes may not fully reverse after stopping Depo and may increase the risk of fractures
