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Journal of Biological Chemistry 290 (49): 2916729177

In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]

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The synthesis of the arginate salt form is more complex than the acetate version