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However, extensive research has verified that GLP-1RAs exert anti-inflammatory actions in various tissues and organs by modulating inflammatory and immune responses (Fig

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(ii) comprehensive pharmacokinetic, biodistribution, and long-term toxicology profiles validated in large-animal models (e.g., canine osteosarcoma, which closely mimics human disease)

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Enrollment in that trial, which is run by the Cleveland Clinic Coordinating Center for Clinical Research (C5Research) and co-chaired by Dr