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VIP also regulates circadian rhythm via hypothalamic signaling, supports gastrointestinal motility and barrier integrity, and has immunomodulatory effects by reducing pro-inflammatory cytokines and promoting immune tolerance

Histamine flares can happen: Even though VIP may have antihistamine and mast-cell-calming effects long-term, some sensitive patients may initially flare with histamine-like symptoms

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[47] Glucose metabolism may be affected, with some patients potentially developing impaired glucose tolerance or diabetes mellitus

Its legality depends on the country and intended use