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You should not take semaglutide if you are allergic to it or if you have conditions, such as: Stomach or intestinal disorder Kidney disease Pancreatitis Retinopathy (eye problems caused by diabetes) Diabetic ketoacidosis Family or personal history of thyroid cancer Multiple endocrine neoplasia type 2 (tumors in your glands) Pregnancy Side Effects of Semaglutide Semaglutide may cause side effects, such as: Diarrhea Nausea Vomiting Heartburn Burping Stomach pain Constipation Headache Low blood sugar in patients with type 2 diabetes Flatulence (gas buildup) Indigestion

Research also suggests glutathione may play a role in treating several neurological conditions, including Parkinsons disease and multiple sclerosis

Additionally, patients who received orforglipron 36 mg lost 19.7 pounds compared with 11.0 pounds with oral semaglutide 14 mg, representing a 73.6% greater relative weight loss

Although the number of events was small and the duration of follow-up short, patients randomised to oral semaglutide experienced a ~50% reduction in cardiovascular death (HR=0.49, 95% CI 0.27 to 0.92) and all-cause mortality (HR=0.51, 95% CI 0.31 to 0.84) (Figure 2)

Family history of thrombophilia or known inherited clotting disorders also elevates baseline risk