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All chronic diseases, including COVID-19 with the long-COVID-19-syndrome (271), are characterized by the presence of persistent chronic inflammation and sustained generation of reactive oxygen and nitrogen species that when confronted with inadequate antioxidant defenses (likely leading components of anti-inflammaging) precipitate excessive oxidative stress
It is a 31 amino acid long peptide hormone (7) mainly secreted by enteroendocrine L cells in the distal intestine, alpha cells in the pancreas, and by the preproglucagon (PPG) neurons located in the nucleus of the solitary tract of the caudal brainstem (6)
When reconstituted with a sterile diluent, it maintains structural integrity for experimental testing
Scars typically lack hair follicles, so their preservation during healing represents a step toward more normal tissue regeneration rather than simple scar formation
Dec 2013;20(6):614-624
