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By antagonizing p53 activity, such as the O-GlcNAcylated c-Jun (the first discovered oncogenic transcription factor), cell death can be prevented ( Research has shown that p53 can suppress the expression of SLC7A11, a key component of the cystine/glutamate antiporter (X c system), leading to the inhibition of cystine uptake and sensitization to ferroptosis
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Furthermore, choline converts to betaine, which serves as a methyl donor and helps convert homocysteine back to methionine (1)
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