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This reaction requires the release of a methyl group from CH3-H4folate to H4folate, the two main circulating forms of folic acid (vitamin B9) in pigs (Natsuhori et al., 1996)

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Moreover, newer GLP-1 RAs and the long half-life of dual agonists (up to 7 days for Semaglutide) give rise to longer preoperative fasting period requirements and concerns of perioperative management of patients, even in case of treatment interruption [15,16,17]