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In the Lp(a) transgenic mouse model, the plasma levels of LY3473329-HCl salt increased in a dose-dependent manner, and treatment with LY3473329-HCl reduced the levels of Lp(a) with an absolute ED 50 of 3 mg kg 1 , with a maximum Lp(a) reduction of 92% after five days of BID oral dosing (Extended Data Table 5 and Fig
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These were predominantly mild to moderate and occurred mainly during dose escalation
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