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The interaction of GLP-1 with the GLP-1R increases insulin secretion in response to glucose and decreases glucagon levels through increasing intracellular cyclic adenosine monophosphate (cAMP) [7]

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HEK293-SNAP-GLP-1R cells generated by stable transfection of pSNAP-GLP-1R (Cisbio, Paris, France) into HEK293 cells (Buenaventura et al ., 2019) were used for some experiments, and maintained in DMEM supplemented with 10% FBS, 1% penicillin/streptomycin and 1 mg/ml G418