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The molecular and genetic mechanisms involved in HD are well understood, but available therapies mostly treat symptoms rather than addressing the underlying cause of this condition (56)
Broad-spectrum antibiotics particularly fluoroquinolones (ciprofloxacin), cephalosporins, and clindamycin indiscriminately kill beneficial Lactobacillus and Bifidobacterium species, removing the primary biological competition that keeps Candida in check
Improvement of sleep cycle and circadian rhythm
Therefore, we suggest that the response observed is a dynamic adaptation to 5FU-imposed pyrimidine stress
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