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The clinician should also determine the onset and duration of the lesion, the presence of systemic signs and symptoms, drug use and smoking habits as well as the number, distribution, size, shape and colour of the pigmentation

Although findings from clinical studies are promising, there are concerns that long-term exposure of GLP-1 RAs at supratherapeutic or maximum approved maintenance doses may impair muscle cell differentiation and potentially contribute to the development of sarcopenia, despite their potential to improve muscle metabolism and quality [83, 88]

[6] In a related manner, GLP-1 agonists can combat lipotoxicity by promoting the breakdown of fatty acids

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