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Pathways such as the Wnt/-catenin, Hippo/YAP, Notch, Hedgehog, TGF-, PI3K-AKT, TNF-, and IL-6 signaling pathways involve complicated systems of receptors, signaling molecules, secondary messengers, transcription factors, and effectors that are crucial for normal liver repair and regeneration

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doi: 10.1056/NEJMoa1911303 63 PackerMAnkerSDButlerJFilippatosGPocockSJCarsonPet al