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Any diagnostic or therapeutic inference drawn from the group-level GSH reduction therefore remains hypothesis-generating, and would need to be confirmed in larger, independent cohorts using longitudinal designs and ideally more objective indices of disease activity, such as prospective headache diaries or attack-phase measurements

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doi: 10.1016/j.ejphar.2008.03.059 132 TataranniTAgriestiFMazzoccoliCRuggieriVScrimaRLaurenzanaIet al