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Attempts to reclassify injectable B12 to a Pharmacy (P) or General Sales List (GSL) medicine have consistently met resistance from the Medicines and Healthcare products Regulatory Agency and the government, based on two key legal criteria outlined in the Human Medicines Regulations 2012 : 1

Expectations and timeline Users typically report initial effects within the first two weeks of use

So the benefit is real, but it is indirect and it depends on whether you were low to begin with

How long to recover from vitamin B12 deficiency

However, a large amount of air can be dangerous, painful and a reason for B12 injections gone wrong. To remove air bubbles from a syringe, hold it upside down and flick its side several times until all air has risen to the top