Coming up: It was four weeks ago when the Nets lost by 53 points in Detroit, and theyre back at Little Caesars Arena on Saturday, the end of a stretch of seven straight games against teams with winning records

Patients should contact their GP or diabetes specialist nurse if they experience: Persistent or severe nausea and vomiting that prevents adequate food or fluid intake, as this may lead to dehydration and electrolyte imbalances Severe abdominal pain , particularly if constant or accompanied by fever, as this could indicate pancreatitisa rare but serious adverse effect requiring immediate assessment Signs of dehydration including dark urine, dizziness, reduced urination, or extreme thirst Unexplained weight loss exceeding clinical targets or accompanied by other concerning symptoms Difficulty swallowing or persistent reflux symptoms that do not respond to dietary modifications Symptoms of hypoglycaemia (low blood glucose) such as trembling, sweating, confusion, or palpitations, especially if taking sulfonylureas or insulin alongside tirzepatide Right upper abdominal pain, fever or yellowing of the skin or eyes , which could indicate gallbladder disease Patients should seek urgent medical attention (call 999 or attend A&E) if they experience: Severe, persistent abdominal pain radiating to the back (possible pancreatitis) Repeated vomiting preventing any fluid intake Signs of severe allergic reaction including facial swelling, difficulty breathing, or widespread rash Severe constipation with abdominal distension and vomiting (possible intestinal obstruction) Important additional considerations: Tirzepatide should not be used during pregnancy or breastfeeding Women using oral contraceptives should use additional contraception for 4 weeks after starting tirzepatide and for 4 weeks after each dose increase, as the medication may reduce contraceptive effectiveness Patients should report any suspected side effects via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk) Routine dietary review with a registered dietitian or diabetes specialist nurse is advisable for all patients starting tirzepatide

Centrally, GLP-1 is largely produced in the brainstem and subsequently transported to key hypothalamic regions, decreasing food intake and body weight
Women with pre-existing diabetic eye disease who are considering any potent glucose-lowering therapy should discuss appropriate ophthalmological monitoring with their specialist
Common Dosing Semaglutide and tirzepatide dosing depends on your medication's concentration, which can vary by pharmacy