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Institute of Medicine says, Since 10-30% of older people may malabsorb food-bound B12, it is advisable for those older than 50 to meet their RDA mainly by consuming foods fortified with B12 or a B12-containing supplement (IOM, 1998, p

A 2025 IV safety study in two healthy human volunteers administered doses up to 20 mg without adverse events the highest quality human safety data currently available, but from only two subjects