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Unlike traditional cell therapies that require harvesting and re-engineering a patient's cells outside the body, Sail's platform is designed to reprogram immune cells directly inside the body, an approach the companies say could make CAR T manufacturing simpler and more scalable while delivering durable, potentially curative results

Pharmacokinetic parameters after intravenous administration in rats showed Dihexa possessed a long half-life of 12.68 days and was extensively distributed, indicated by a large volume of distribution (Va)

PMID 39025385

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