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As the native GLP-1 has a short half-life, GLP-1 analogues have been produced to prolong effects and many of them could cross blood-brain barriers (BBB) such as Liraglutide (LG), lixisenatide, and exendin-4
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Spotlight on the Mechanism of Action of Semaglutide
Retatrutide is investigational and not approved for human use
-cell GLP-1R signaling activates -cell GLP-1 production via paracrine signaling factors
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