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When the organism encounters internal or external stressorsbiological, physical, or chemicalthat disrupt cellular homeostasis, ROS production may exceed elimination capacity, resulting in ROS accumulation

The most common mild to moderate digestive side effects included: nausea constipation diarrhea vomiting indigestion No liver-related safety concerns were observed

A sensitivity analysis was conducted and showed no differences related to sex or type 2 diabetes prior to MBS in the need for pharmacological therapy or the requirement for medication with a dose greater than or equal to 150 mg/day

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Buffoni F, Pino R, Dal Pozzo A