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This overview synthesizes key findings on its cytoprotective mechanism and experimental applications in wound healing, tendon repair, gastrointestinal models, and angiomodulation

However, the American Gastroenterological Associations latest clinical update does not support this precaution

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The injection of methotrexate caused an increase in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cholesterol, triacylglycerides, and low-density lipoprotein-cholesterol, and a decrease in high-density lipoprotein-cholesterol (HDL-cholesterol)