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Patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should avoid GLP-1 medications
The body interprets the combination of low nutrition and unstable signaling as a stressor, leading to: Increased hunger Reduced metabolic rate Heightened fat-storage efficiency This explains why many people feel constantly hungry and fatigued while following calorie-restricted diets based on processed foods (17)
Not trace amounts
By preventing the binding of natural ligands such as myostatin and activinwhich normally suppress muscle growththese agents simultaneously promote skeletal muscle hypertrophy (increasing lean mass) while reducing fat mass
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