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A study comparing semaglutide to testosterone replacement therapy found that semaglutide was better at improving weight and muscle composition while keeping sperm quality healthy

Insulin resistance: Paradoxically, while acute IGF-1 LR3 administration enhances insulin sensitivity, some research suggests chronic administration may produce compensatory insulin resistance over extended periods (12+ weeks)

As the oxidative burden on the nervous system decreases, the autonomic nervous system can begin to shift back toward parasympathetic dominance (the "rest-and-digest" state)

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10.1016/j.jsbmb.2009.12.005 18 BuchwaldH.EstokR.FahrbachK.BanelD.JensenM