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By activating FXRs in both the intestine and the liver, OCA is hypothesized to lessen liver exposure to toxic bile acids, leading to anti-inflammatory and anti-fibrotic effects [99,100]

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Some nanoparticles can sensitize effective ferroptosis, produce mild immunogenicity, and improve the response rate of non-inflammatory tumors in cancer immunotherapy [218]

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The resulting acetoxyarylamines are highly unstable, spontaneously forming arylnitrenium ions that bind to DNA (Bland & Kadlubar, 1985) and ultimately lead to mutagenesis and carcinogenesis (Kerdar et al., 1993)