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During the transition: Monitor blood glucose more frequently for the first 4 to 6 weeks Expect potential hypoglycemia risk if also taking insulin or sulfonylureas Your provider may need to adjust other diabetes medications A1C improvements may be more pronounced with tirzepatide The SURPASS clinical trials demonstrated that tirzepatide 15 mg reduced A1C by up to 2.58%, compared to semaglutide 1 mg which reduced A1C by 1.86%

This regulatory position reflects the lack of validated safety data

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These factors must be taken into account when assessing the balance of benefits and risks for using GLP-1 medications, he said

Its not ethical to conduct medication trials on pregnant humans, so researchers rely on animal models and observational data from accidental exposures