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The purpose of the appendix is not known
Results depend on a patients lifestyle, activity level, genetics, and metabolism
10.1016/j.envexpbot.2007.06.007 191 ValpuestaV.BotellaM
Until that data becomes available, the Phase 2 results showing no thyroid safety signals, combined with the broader class experience, suggest the thyroid concern does not materially differ between GLP-1 medications
GLP-1RAs appear to favor pro-survival responses in -cells, heart, brain and bone where the IGF-1/IGF-1R system appears to play an important role
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